Soyuz MS-16 was Soyuz spaceflight launched on 9 April 2020, which transported three members of the Expedition 62/63 crew: NASA astronaut S. Cassidy, cosmonauts A. Ivanishin and I. Vagner to ISS.

 This flight was the first crewed launch using the Soyuz 2.1a launch vehicle, and the first crewed Russian mission not to launch from Gagarin's Start (which began modernization renovations after Soyuz MS-15) since Soyuz MS-02 in 2016.